Polyphenols have recently become an important focus of study in obesity research. Oligonol is an oligomerized polyphenol,\ntypically comprised of catechin-type polyphenols froma variety of fruits, which has been found to exhibit better bioavailability and\nbioreactivity than natural polyphenol compounds.Here,we demonstrated that Oligonol inhibits 3T3-L1 adipocyte differentiation by\nreducing adipogenic gene expression. During adipogenesis, Oligonol downregulated the mRNA levels of peroxisome proliferatoractivated\nreceptor ???? (PPAR????), CCAAT/enhancer binding proteins ???? (C/EBP????), and ???? (C/EBP????) in a dose-dependent manner and\nthe expression of genes involved in lipid biosynthesis. The antiadipogenic effect of Oligonol appears to originate from its ability to\ninhibit the Akt and mammalian target of rapamycin (mTOR) signaling pathway by diminishing the phosphorylation of ribosomal\nprotein S6 kinase (p70S6K), a downstreamtarget ofmTOR and forkhead box protein O1 (Foxo1). These results suggest that Oligonol\nmay be a potent regulator of obesity by repressing major adipogenic genes through inhibition of the Akt signaling pathway, which\ninduces the inhibition of lipid accumulation, ultimately inhibiting adipogenesis.
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